The SITUS JUDI MBL77 Diaries
This methylation profile is previously obtained on the MBL stage3 and stays reasonably stable after some time. Even so, some CLL have intratumor variability in specific locations, which can change the expression of quite a few genes and aid tumor evolution.71 Of note, this variability is larger in U-CLL than in M-CLL which is affiliated with growin